AiPP: Artificial Intelligence Protein Profiling

Webmaster: G.W. Dayhoff II

About AiPP

AiPP illuminates ligandable sites across the human proteome, including drug targets undetected or unliganded by ABPP.

Of the 19,486 unique proteins in the human proteome (UniProt database https://www.uniprot.org/), 9,580 have not been detected and 3,362 have not been liganded by ABPP (as in the LigCysABPP database). A total of 1,860 proteins (1,472 ABPP liganded and 388 ABPP unliganded) are in the model training set. Drug targets within ABPP undetected or unliganded proteins are stratified by functional family classifications.

How to use

  • Explore — search the AiPP Atlas by UniProt ID or gene symbol.
  • Predict — score any sequence not in the Atlas (ESM Forge token required).
Figure panels showing human proteome coverage and Top-1 score distributions for drug targets unseen by ABPP

🔎 Explore

Explore the AiPP Atlas (v1) comprising precomputed predictions and curated chemoproteomic data for human proteins.

(note: proteins comprising 2046 or fewer residues)

🤖 Predict

Use AiPP to profile any sequence not already covered in the AiPP Atlas: non-human, custom constructs, or variants.

(note: an ESM Forge Token is required)